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KMID : 0613820110210020279
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Journal of Life Science
2011 Volume.21 No. 2 p.279 ~ p.285
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Antimelanogenic Effect of Ligularia fischeri, Solidago virga-aurea, Aruncus dioicus Extracts from Ullung Island in Murine Melanoma Cells
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Kim Dong-Hee
An Bong-Jeun
Kim Se-Gie
Park Tae-Soon
Park Gun-Hye
Son Jun-Ho
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Abstract
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The objective of the present study was to evaluate the skin whitening effect of the extracts of 3 herbs, Ligularia fischeri, Solidago virga-aurea and Aruncus dioicus, which were collected from Ullung island. Tyrosinase inhibition activities were 33% in pre-fermented extracts and 45% in post-fermented ones. When tyrosinase activities in B16F10 murine melanoma cells were tested, activities in pre- and post-fermented extracts were 41 and 56.5%, respectively. Thus, the post-fermented extracts might have greater skin whitening effects. The protein expression of MITF, TRP-1, TRP-2, and tyrosinase, which are all skin-whitening related transcription factors, showed that both pre- and post-fermented herbs inhibited protein biosynthesis in B16F10 melanoma cells. Post-fermented herb extracts especially showed a greater decrease of protein expressions. The expression of MITF, a regulatory transcription factor, was also decreased by both extracts but was greater in the post-fermented ones. From the results, it can be concluded that the 3 herb extracts from Ullung island may inhibit melanin biosynthesis by the suppression of MITF activity in a signaling pathway. Results indicate that the post-fermented herbs tested in the present study had skin whitening activities and can be used as functional ingredients for food and cosmetic compositions.
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KEYWORD
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Tyrosinase, MITF, Ligularia fischeri, Solidago virga-aurea, Aruncus dioicus
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